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inotuzumab (CMC-544) ([@B36]). Of the many possible ways to remove B-cell cancers from the circulation, herceptin, anti-CD19, and anti-CD20 have been shown to successfully deplete circulating CLL cells. The results of a phase II single arm trial showed that rituximab could be used in combination with radiation and 2 courses of chemotherapy with an initial response rate of 100% ([@B37]). A rituximab pre-treatment followed by chemotherapy for patients with CLL showed an overall survival of 75% and a progression-free survival of 46% in patients with an objective response of 97.9% ([@B38]). In patients with refractory CLL, the introduction of rituximab resulted in a significant prolongation of median survival to 13.3 years compared to only 5 years with previous therapy ([@B39]).
Another drug with potential activity against CLL is Bruton’s
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